الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Background: Patients with epilepsy commonly report poor sleep quality, increased nocturnal awakenings, early morning awakenings, difficulty initiating sleep, and excessive daytime sleepiness. Nineteen percent of generalized seizures occur during sleep, as compared to 51% of localization-related seizures. One in five patients with epilepsy has seizures exclusively during sleep. Most sleep-related seizures occur out of NREM sleep, with NREM sleep stage N2 being the most common. This sleep stage likely facilitates focal spikes and epileptic activity through thalamocortical hyper synchrony, as represented by characteristic sleep spindles and K complexes. Sleep itself may activate interictal activity in approximately one third of patients with epilepsy and up to 90% of people with sleep-wake-related epilepsies. Patients and Methods:To assess the possible effect of epilepsy activity on sleep architecture and effect of sleep disorders of epilepsy activity in patients attending Mansoura university hospitals, this study was conducted on 25 patients with age range between 15 and 40 years who were diagnosed with idiopathic epilepsy with no psychiatric comorbidities and 25 age matched healthy controls. The characteristics of the patients were investigated as possible correlation between epilepsy activity and sleep disturbances. These factors included information from patients’ history, examination, sleep questionnaires, EEG, brain MRI andPSG. Results: patients with idiopathic epilepsy experience poor sleep quality as evident through higher scores more than five in PSQI and abnormalities in the PSG parameters including reduction in sleep efficiency, SWS stage %, REM sleep%, increase in WASO, increase in PLMI. Second, patient with epilepsy activity showed reduction in sleep efficiency, total sleep time, REM sleep stage% and increase in WASO. Number of AEDs showed important effect on sleep architecture as patients who were on more than one AED as they had significant reduction in REM% and increase in WASO. Patients with JME showed higher prevalence in insomnia than other patients as they had statistically significant delay sleep onset latency. Conclusion: patients with idiopathic epilepsy attending Mansoura university OPC frequently complaining poor sleep quality according to this study. Epilepsy syndrome type, number of AEDs, epilepsy activity were the commonest predisposing factors to poor sleep quality. Measures should be taken to improve quality of sleep in these patients including proper diagnoses of epilepsy syndrome, choice of AED, use monotherapy as much as possible and control of epilepsy activity.