الفهرس 
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Abstract
Hepatitis C virus (HCV) is a major health problem which infects over 180 million humans, and causes over 350,000 deaths per year. Egypt has one of the highest prevalence rates of hepatitis C virus (HCV) infection in the world (16-18%). Currently, no vaccines exist for HCV and the treatment regime of interferon-α and ribavirin is poorly tolerated, costly, and only effective in approximately 50% of patients. Among the six major HCV genotypes found worldwide, genotype 4 is the most predominant in Egypt with 4a as the dominant subtype. Therefore, the present study aimed to investigate and throw more lights on conserved regions of the E2 –P7 genes of HCV genome genotype 4a translated into promising proteins acting as antiviral targets where E2 act as neutralizing antibody (may be effective vaccines) and p7 act as ion channel that may be used in drug design using phylogenetic analysis and secondary and 3-D structure prediction of both the E2 and p7 proteins in the HCV genotype 4a detected in different countries.