الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Iron deficiency anemia (IDA) and Beta thalassemia trait (BTT) are among the most frequent causes hypochromic microcytic anemia in our environment. In clinical practice, because there is hypochromic microcytic mild anemia and a peripheral smear resembles (IDA), these two disorder must be distinguished from each other. Moreover there is frequent occurrence of (IDA) in patients with beta thalassemia trait which potentially can confound the diagnosis of the later.
Objectives: The aim of this study is to evaluate platelets indexes in differentiation between β -thalassemia trait and (IDA) to facilitate rapid discrimination between these two common causes of hypochromic microcytic anemia.
Patients and Methods: This study was conducted at Pediatric Hematology, Oncology Unit, Ain Shams University Children Hospital, 44 children of β -thalassemia trait (group A) and 4 children combined of beta thalassemia triat and iron deficiency anemia diagnosed out of group B after laboratory investigations (group c) on 40 children of iron deficiency anemia (group B). All groups were subjected to full history taking and examination. They were subjected to Complete Blood Count (CBC) with differential leukocytic count, RBCs indexes (Mean corpuscular volume (MCV), Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC) and RBCs distribution width (RDW), platelets indexes Mean Platelet Volume (MPV) and Platelet distribution width (PDW). Iron profile (serum iron, transferrin, total iron binding capacity level and serum ferritin) and hemoglobin electrophoresis.
Results: The study included 40 patients of beta thalassemia trait BTT (group A), their age was ranging from 1.6 to 18 years (8.67 ± 4.17). The second group included 40 patients of iron deficiency anemia IDA (group B). Males and females were (50%). Hb concentration, HTC, RBCs, serum ferritin and transferrin index were statistically significantly higher in group B than group A, while MCV, MCH , RDW and Mentzer index are significantly higher in group A than group B. White blood cell count is significantly higher in group A than B. Regarding platelet count, PDW, MPV there were no statistically significant difference between both groups, however statistically significant positive correlations were detected between MPV and RDW, between platelets and MCHC, and between platelets and WBCs in group B. Significant negative correlations between platelet count and PDW and between PDW with Hb and MCHC were also detected in same group. Regarding group A, high significant negative correlations is detected between MPV and PDW, and significant positive correlations between MPV and RDW and between platelets and WBCs. A group of 4 patients with combined beta thalassemia trait and iron deficiency anemia was detected MPV is significantly lower in this group than in beta thalassemia trait.
Conclusion: Platelets indices can’t be used to distinguish between both types of anemias especially MPV There was no stastically difference between both groups, but cases of combined IDA and Beta thalassemia trait showed significant lower MPV than both groups of beta thalassemia trait and iron deficiency anemia.