الفهرس | Only 14 pages are availabe for public view |
Abstract Wasting is a systemic manifestation of tuberculosis and is often thought to affect the severity and outcome of the disease. When tuberculosis infection occurs, a variety of chemokines and cytokines are secreted from infected cells and tissue macrophages. TNF alpha and several cytokines are thought to play a role in the relationship between TB, nutritional status and host immune response. TNF alpha increases early in the disease and takes part in the pathogenesis and prevention of mycobacterial infection. This study was carried out on 40 active pulmonary TB patients in (group A) in addition to 10 apparently healthy subjects (group B). The patients were classified into 3 subgroups according to lesion: (Minimal-lesion, Moderately-advanced lesion and Far-advanced lesion).TNF-α levels was measured by Sandwich ELISA method before and 2months after treatment. Body mass index (BMI) and chest X-rays were also evaluated. The results of study showed: The mean value of BMI ± SD in TB cases before treatment and TB cases after treatment were (15.97± 2.55, 25.04±31.55) respectively with P value 0.03. The mean value of TNF alpha (17832.00) & SD (23396.87) in TB cases before treatment, The mean value of TNF alpha (13447.00) & SD (4889.65) in TB cases after treatment, the mean value of TNF alpha (278.05) & SD (142.58) in control with P value <0.01. There was significant difference between serum TNF alpha regarding symptomatology before and after treatment with significant P value <0.001 and there was positive correlation between serum TNF alpha and clinical severity among cases with significant P value 0.003. There was negative correlation between serum TNF alpha and BMI among cases with significant P value <0.05. There was significant difference between serum TNF alpha regarding radiology before and after treatment with significant P value <0.001. There was positive correlation between serum TNF alpha and radiological severity among cases with P value <0.086 There was significant difference between serum TNF alpha regarding sputum Ziel Neelsen stain before and after treatment with significant P value <0.001. There was positive correlation between serum TNF alpha and laboratory severity stain among cases with P value 0.148. from this study, it can be concluded that: 1- Serum TNF-α level was significantly higher in tuberculous group as compared to control group. 2- Significant negative correlations were found between serum TNF-α and BMI in tuberculous group. 3- Significant positive correlations were found between serums TNF-α and clinical severity in tuberculous group. 4- Insignificant positive correlations were found between serums TNF-α and radiological severity in tuberculous group. 5- Insignificant positive correlations were found between serum TNF-α and laboratory severity in tuberculous group. |