الفهرس 
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Abstract
The Skin Is Organ That In Direct Contact With The Environment And It Represents Possible Door For The Entrance Of Therapeutic Agents Into The Body. Because Of The Increasing Incidence Of Viral Infection For The Skin, Antiviral Drug Delivery Is Emerging As A Non-Invasive And Attractive Approach For The Treatment Of Several Viruses. Acyclovir (ACV) Is An Antiviral Drug That Is Primarily Used For The Treatment Of Herpes Simplex Virus Infections, Chickenpox. ACV Is Also Categorized Class III Drug Because Of Its High Solubility And Low Permeability According To The Biopharmaceutical Classification System (BCS) And Low Partition Coefficient May Reflect The Low Membrane Permeability Of ACV.
Significance Of Particle Size:
The Sub-Micron Size Of Nanoparticles Offers A Number Of Distinct Advantages Over Microparticles. Nanoparticles Have In General Relatively Higher Intracellular Uptake Compared To Microparticles. The Efficiency Of Uptake Of 100 Nm Size Particles Was 15-250 Folds Greater Than Larger Size Microparticles. Particle Size Significantly Affects Cellular And Tissue Uptake, And In Some Cell Lines, Only The Submicron Size Particles Are Taken Up Efficiently But Not The Larger Size Microparticles.
Gold Nanoparticles And Nanoliposomes Are Effective New Technology In Delivering The Bioactive Agents And Enhancing Their Performance By Increasing The Bioavailability. The Goal Of The Present Study Was The Formulation Of Liposome For The Use As A Carrier For Nanogold Conjugated With ACV, Antiviral Drug, To Enhance ACV Delivery.
Methods:
The Gold Nanoparticles Were Used As A Capping Agent For ACV And Sodium Citrate Was Used As Reducing Agent For The Gold. Transmission Electron Microscopy Was Used For characterization And To Study The Morphological And Structural Properties Of Drug-Metallic Nanostructures. Nanoliposomes Were Formulated Using Different Molar Ratios Of A Positive charge Inducer (Stearylmine) Or A Negative charge Inducer (Dicetyl Phosphate), Lecithin, Cholesterol And Span 60.
Results:
Gold Nanoparticles With A Particle Size Of 10–20 Nm Were Formed. This Small Size Of The Formed Particles Has A Clear Effect In Reducing The Gold Nanoparticles Toxicity And Enhances The Cellular Uptake. The Amount Of Sodium Citrate Used In This Preparation Influences The Size Of Gold Nanoparticle. The Present Study Employed 1% Trisodium Citrate, Which Contains A Carboxylic group Which Works As A Reducing And Capping Agent, To Synthesize ACV- Gold Nanoparticles Conjugate. Liposomal Formula F6 Had The Highest Entrapment Efficiency Approaching 42%, Low Particle Size Of 160 Nm, And Zeta Potential Of 43.5 Mv.
It Is Evident from The Study That The Liposomes Can Be Used As A Carrier Of ACV Conjugated With Gold Nanoparticles. This New Strategy Could Be Used Successfully In The Treatment Of Viral Infection.