الفهرس 
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Abstract
The prevalence of vitamin D deficiency is high type-1DM .vitamin D regulates both innate and adaptive immunity, thus indicating its potential role in preventing and treating T1DM.It is also evident that vitamin D deficiency cannot be the sole determining factor of T1DM. Clearly, both genetic and environmental factors determine the development of the disease. from the existing data, it could be postulated that optimal doses of vitamin D supplementation may influence the pattern of immune regulation and subsequent progression to T1DM in a genetically susceptible individual. However, more studies are required to substantiate the relation between T1DM and vitamin .Vitamin D analogues in the pattern of immune regulations in susceptible individuals (Harinarayan, 2014).
Aim of the study:
The study’s primary aim was to investigate the 25 (OH) vitamin D level in patients with T1DM and presence and absence of tTG (IgA) antibodies and relation between vitamin D level and positivity and negativity tTG (IgA) antibodies.
Patients and methods:
The current study is cross sectional case-control study included 90 persons that were divided into two groups; 75 patients with T 1 DM , and 15 persons were taken from the outpatient Clinic of endocrine and metabolism at Minia university Hospital, in the period from March 2015 to November 2015.
All patients and controls were subjected to:
A-Full history taking.
B-Clinical Examination
C- Laboratory investigations:
Blood samples for: routine lab. Investigations (CBC. HbA1c. Renal functions, liver enzymes, lipid profile, FPG and PPG) and special investigations (Detection of tTG (IgA) antibodies and assess level of 25 (OH) D by ELISA.
D- Statistical analysis:
The data were coded, entered and processed on an IBM-PC compatible computer using SPSS (version 19).
The study revealed that:
The level vitamin D decreased in diabetics patients with mean (17.6±17.2) compared to control subjects with mean (44.4±31.8) as p value (0.001*).
Out of 75 diabetic patients studied, 37.3% (28 patients), were vitamin D deficiency , 45.4% (34 patients) were insufficiency and 17.3% (13 patients) were Sufficient as p value 0.009*.
Vitamin D deficient had a significant predominance of female gender as from 28 patients with vitamin D deficiency and 64.3% (18 patients) were females.