الفهرس 
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Abstract
The repair of extensive bone defects, caused by either traumas or
pathologies, constituted a great problem for both Medicine and
Dentistry. Despite the great potential of repair by bone tissue, in some
situations, according to the proportion of defects, the regeneration
cannot be completed because the defect can be invaded by the
surrounding conjunctive tissue which has a proliferation and cellular
migration speed faster than those of bone tissue. Thus, the use of bone
grafting can collaborate with the repair process.
The presence of osteoblasts is an important requisite in the
effectiveness and success of the bone repairing. This osteoblastic
differentiation is commonly evaluated through different protein markers,
among them bone morphogenetic protein-2 (BMP-2).
In the recent past, a multitude of drugs or components with antiresorptive,
anabolic or even combined activities have been identified
and their effect is still under investigation. One such new experimental
drug is simvastatin – a statin which has shown promising results in
fracture healing in rodents. Studies have shown that statins may exert
bone anabolic effects through increasing the expression of BMP-2 and
thus, may enhance fracture healing (1). In view of the recent
developments, the present study was undertaken to assess the effect of
simvastatin on the expression of BMP-2 and its influence on bone
repair.