الفهرس 
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Abstract
Aspartame is an artificial sweeter. It is found in more than 6000 food products. Recent studies show that the chronic use of ASP has a harmful effect on histological structure of cerebellar cortex due to oxidative stress. On the other hand, anisum oil and SE are antioxidant substances. Therefore, the present study was performed to study the microscopic and morphometric alterations in the cerebellar cortex in adult male albino rats after administration of ASP for two months and the possible protective effect of anisum oil versus SE on these changes.Forty-eight adult male albino rats weighing 180-200 grams were used in this study and randomly divided into four main groups. group I (Control group) included 12 rats that were subdivided into three subgroups. group Ia included 4 rats which received 0.5 ml of distilled water/day by intraperitoneal injection for 2 months. group Ib included 4 rats which received 0.5 ml/kg/day anisum oil by an intraperitoneal injection for 2 months. group Ic included 4 rats which received 0.5 mg/kg/day selenium dissolved in distilled water by intraperitoneal injection for 2 months. group II included rats which received 250 mg/kg/day aspartame dissolved in distilled water by an intraperitoneal injection once daily for 2 months. group III included rats which received 0.5 ml/kg/day anisum oil by an intraperitoneal injection 2 h before aspartame administration. group IV included rats which received 0.5 mg/kg/day selenium dissolved in distilled water by intraperitoneal injection 2 h before aspartame administration. At the end of the experiment, rats were anesthetized by intraperitoneal injection of sodium pentobarbital. Cerebellum was rapidly obtained and processed to prepare paraffin sections for histological