الفهرس 
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Abstract
Background: Antipsychotics (neuroleptics) are a class of psychiatric medications primarily used to manage psychosis in cases of schizophrenia, bipolar disorder, acute mania and agitation. Consequently, the principal manifestations of typical antipsychotic overdose involve the central nervous system (CNS) and cardiovascular systems (CVS) with increased risk of sudden death. Aim: To study the acute toxicity of typical and atypical antipsychotics as regards the incidence of cardiovascular and neurological complications in patients admitted to the poison control centre ain shams university. Patients and Methods: The current study is a retrospective study, included all patients diagnosed with acute single antipsychotic overdose, admitted to the Poison Control Center, Ain Shams University Hospitals (PCC, ASUH) during the period from January 2013 to December 2015. The total number of acute antipsychotics intoxicated patients was 375, including all patients aged from one year to eighty-five years who ingested a single antipsychotic drug. They were 213(56.8%) adult and 162 (43, 2%) children. Results: No significant difference was present on comparing neurazine and clozapex overdose as regards sex, delay time and manner of toxicity among both ICU admitted children and adults. No significant difference between inpatient admitted adults acutely intoxicated with clozapex and neurazine as regards duration of hospital admission.
Keywords: Acetylcholine (Ach), Central nervous system (CNS), Poison Control Center (PCC).