الفهرس 
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Abstract
Preservatives consider one of the most important food additive that used in most food industries like meat, fish, oil and others. The aim of the present study is to determine the effect of different doses and durations of two different preservatives, sodium nitrite and monosodium glutamate (MSG). The experiment was carried out on 50 adult male rats weighing 150-200 gm. They have been divided into 5 groups,10 in each group (control group, second and third group were maintained on ration contains sodium nitrite at concentration 0.2% and 0.4% of the diet respectively, fourth and fifth group were maintained on ration contains MSG at concentration 0.04mg/kg and 0.08 mg/kg of the diet respectively). Samples were collected after 6weeks. The biochemical results of sodium nitrite administrated rats showed significant increase in urea, creatinine, and MDA. Increase activity of ALT, AST. In addition, increased glucose level was detected .And there were decrease in testosterone hormone , GSH, body weight and hemoglobin concentration. The bio-chemical results of MSG treated rats showed increase in body weight, urea, creatinine level, MDA and glucose level. Moreover, increase activity of ALT, AST were seen. Liver , kidney and testicles sample were subjected to histo pathological lesions.