الفهرس 
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Abstract
Platelet rich plasma (PRP) is a simple, low-cost, and minimally
invasive method that allows a high concentrate of autologous growth
factors in physiologic proportions to be obtained from blood, which can
be easily and safely injected.
Transforming growth factor-beta-1 (TGF-B1) induces a positive change
in the articular environment, regulate angiogenesis, and induce the
synthesis of hyaluronic acid in the synovial membrane.
Intra-articular injection of autologous PRP has been increasingly
implemented on patients with osteoarthritis. PRP reduces pain and
improves function over time and currently seems to be considered as
one of the treatment options for osteoarthritis.
The aim of this study was to determine the efficacy of intra-articular
injections of PRP in patients with Knee Osteoarthritis.
This study was carried out on 35 patients suffering from primary knee
osteoarthritis grade I, grade II and grade III.
There were 24 female and 6 male patients. Their age range from 30 to
65 years with average 52 years, their body mass index (BMI) ranged
from 22.2 to 54.11 kg/m2 with average 38 kg/m2, the period of
complaint ranged from 3 to 108 months with average 25 months, the
laterality was left (11 cases) and right (19 cases), grade was 2 cases
grade I, 23 cases grade II and 5 cases grade III.
All patients were treated by 2 intra-articular injection of PRP treatment,
post injection follow up period was 1 year .
The clinical results were classified on subjective base and were graded
as Excellent in 19 patients (63.3 %), Good in 6 patients (20 %) and Poor
in 5 patients (16.7 %).
Platelets had significant effect on the results as it increased, activated
and released growth factors which had role in osteoarthritis
improvement.
Age and Sex had no statistically significant effect on the results.
Period of complaint had statistically no significant effect on results.
Grade of osteoarthritis had statistically significant effect on results as
the more degeneration of the joint the less viable cells the smaller
potential for growth factors response.
Body mass index (BMI) had statistically significant effect on results as
the large weight cause cartilage degeneration.