الفهرس 
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Abstract
The aim of the present work is to design and synthesize some novel thiodiacetic acid based bishydrazone ligands and study their coordinative behavior towards some of first raw transition metals. All prepared compounds were characterized employing elemental analysis, spectroscopic (IR, UV-visible, 1HNMR and ESR) as well as magnetic and thermal measurements. Furthermore, due to the valuable bioactivity of the hydrazones, the antimicrobial efficiencies as well as SOD-like activities for all investigated compounds were assessed. The obtained results can be summarized as follow:1.New bishydrazone Schiff bases namely, 2,2’-thiobis(N-benz-ylidene)acetohydrazide) (H2TBAH), 2,2’-thiobis(N’-(thiophen-2-ylmethylene) acetohydrazide) ( H2TTAH) , 2,2’-thiobis(N’-(furan-2-ylmethylene)acetohydrazide) (H2TFAH), 2,2’-thiobis(N’-(2-nitrobenzylidene)acetohydrazide) (H2TNAH) and 2,2’-thiobis(N’-(2-hydroxy-benzylidene)acetohydrazide) (H2TSAH) have been isolated and fully ascribed.2.The coordination compounds of these ligands with Fe(III), Co(II), Ni(II), Zn(II) as well as various Cu(II) salts have been prepared and structurally elucidated.3.The proposed chemical formulae of the ligands and their metal complexes are in good agreement with the stoichiometries derived from their analytical data of carbon, hydrogen and metal contents.4.Different modes of chelation for the ligands were suggested based on careful comparison between the spectra of the ligands and those of their corresponding complexes.5.The thermal behavior of the prepared bishydrazones and their metal complexes was investigated using TGA and DTG and the corresponding kinetic parameters were evaluated.6.The optimized molecular structures for all compounds as well as the execution of some theoretical calculations were determined using DFT method.7.The potential antibacterial and antifungal efficacies as well as the super oxide dismutase (SOD) like activity for all compounds were tested.