الفهرس | Only 14 pages are availabe for public view |
Abstract Rabbits are quite prone to respiratory diseases. The bacteria most often involved in these complications include Pasteurellamultocida and Staphylococcus aureus. Cefquinome is the first member of fourth generation cephalosporins developed for use in veterinary medicine. The in vitro and in vivo efficacy of this drug against a wide rang of gram –ve and gram +ve bacterial pathogens. Ascorbic acid is reported to have a stimulating effect on the phagocytic activity of leukocytes, the function of the reticuloendothelial system and formation of antibodies. As an effective scavenger of reactive oxygen species, ascorbic acid minimizes the oxidative stress associated with the respiratory burst of activated phagocytic leukocytes, thereby functioning to control the inflamma¬tion and tissue damage associated with immune responses. Ascorbic acid levels are very high in phagocytic cells, with these cells using free radicals and other highly reactive oxygen containing molecules to help kill pathogens that invade the body. In the process, however, cells and tissues may be damaged by these reactive species. Ascorbic acid helps to protect these cells from oxidative damage. The current study was outlined to look into some pharmacological studies on cefquinome, giving an example of its consequences (liver function, kidney function tests, and CBC and antioxidant enzymes activities), hopefully seeking a possible way out from the cefquinome side effects through the use of antioxidant vitamin C. |