الفهرس 
Historical overview of nanoparticlesOnly 14 pages are availabe for public view
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Abstract
Introduction: Silica oxide nanoparticles (SiO2NPs) have a dominant medical role because of their fundamental characteristics. They have a wide range size (from 5 to 1000 nm). They possess unique optical properties, high specific surface area, low density, adsorption capacity, capacity for encapsulation, biocompatibility and low toxicity. These features led to their wide use in biomedical applications as catalyst supports, drug carriers, and gene delivery.
Aim of the work: To assess the effect of different doses and durations of intravenous injections of SiO2NPs on the hepatic tissue structure of adult male albino rats.
Materials & methods: Forty Wister male albino rats were divided randomly into three groups. group I; served as control group, group II; injected with 10mg/kg SiO2NPs for two and four weeks and group III; injected with 30mg/kg SiO2NPs for two and four weeks. All doses were given by intravenous injection in the tail vein. At the end of the experiment, liver of all rats was dissected out and processed for histological, immunological and ultrastructural studies. Morphometric measurements and statistical analysis were also performed.
Results: SiO2NPs injections apparently didn’t affect the hepatic lobular organization in any dose or duration. However, they caused hepatocyte vacuolation, mononuclear cellular aggregates, increased Kupffer cells number and increased collagen content. Pit, Ito and oval cells were apparently detected, in addition to signs of epithelial-mesenchymal transition of hepatocytes to myofibroblast-like cells. The affection increased as the dose and duration increased.
Conclusion: SiO2NPs caused inflammatory reaction, activation of Kupffer cell, Ito cell and Pit cell in the liver which increased as the dose and duration increase.