الفهرس 
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Abstract
Asthma is a complex syndrome involved permanent airway obstruction, airway hyperresponsiveness, and multicellular inflammation. Airway inflammation is an essential pathophysiologic characteristic of subacutе asthma. Ovalbumin sensitization and challenge caused marked airway inflammation evidenced by increased lung weight index, infiltration of multiple inflammatory cells especially eosinophils in the bronchoalveolar lavage fluid, obvious change in oxidative stress biomarkers concentration in the lung homogenate e.g MDA, GSH, SOD, elevated levels of lung nitric oxide, increased concentration of IL-13 in lung homogenate and BALF. In addition, histopathological examination revealed increased epithelial cell thickness, mucous gland hyperplasia, goblet cell hyperplasia and presence of numerous mast cells. In the present study, subacute asthma was induced by sensitization of mice with intraperitoneal injection of ovalbumin and aluminium hydroxide at day 0,7 followed by OVA challenge for 3 days from day 14 to day 16. The efficacy of beclomethasone, trimetazidine, flavocoxid and agmatine on the airway inflammation of asthmatic mice was evaluated : The following parameters were evaluated : 1. Lung weight index (lung weight/body weight). 2.Total and differential cell counts in BAL fluid. 3.Oxidative stress biomarkers (MDA, GSH, SOD) in the lung homogenate. 4.Total nitric oxide (NOx) content in the lung tissue. 5. IL-13 level in lung tissue and BALF. 6.Histopathological examination of lung and tracheal specimens and IHC staining of mast cells by CD117 immunostain.
Administration of these drugs exerted good results and improved all previous parameters in comparison with standard beclomethasone inhalation. More clinical studies should be concluded in order to prove the effectiveness of such drugs in asthmatic patients.