الفهرس 
Multiple MyelomaOnly 14 pages are availabe for public view
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Abstract
Multiple myeloma (MM) is a debilitating malignancy that is part of spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. It was the first hematological malignancy in which a prognostic relevance of bone marrow (BM) angiogenesis was reported. Microenvironment formed by reactive oxygen species, growth factors and chemokines initiates the process of BM angiogenesis. Among the angiopoietins, angiopoietin-2 is involved in vessel sprouting. Ang-2 is a protein consisting of 496 amino acid residues which was found that it is expressed only at the sites of vascular remodeling. The aim of this work is to throw more light on the role of angiopoietin-2 in multiple myeloma.