الفهرس | Only 14 pages are availabe for public view |
Abstract Preeclampsia (PE) is a pregnancy specific disorder which is characterized by high blood pressure and large amount of protein in urine usually in the 3rd trimester of gestation and get worse over time. It affects 3 - 17% of pregnancies worldwide and entails serious consequences for both the mother and the fetus. Treg cells constitute a T helper lineage that is derived from thymus (natural Treg cells) or is induced in the periphery (induced Treg cells). Treg cells are enriched at the fetal-maternal interface, showing a suppressive phenotype. In contrast, Treg cells are not increased in the circulation of pregnant women, and the suppressive capacity is similar to that in nonpregnant women. However, aberrations in Treg frequencies and functions, both systemically and in the uterus, may be involved in complications of pregnancy. Our case-control study was conducted on 50 subjects of pregnant women divided into two groups. group (1): case group included 30 pregnant women with preeclampsia (PE). group (2): control group included 20 healthy pregnant women who matched the group (1) for age and mode of delivery. Any pregnant woman complicated by clinical chorioamnionitis, any infectious disorder or preexisting clinical disorders, such as chronic hypertension or renal diseases before pregnancy was excluded from the study. Cord blood samples were collected from both groups and evaluated by flow cytometry for CD4+CD25highFOXP3+ Treg cells. |