الفهرس 
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Abstract
Effect of Danazol on Expression of Endometrial αvβ3 Integrin in Patients with Recurrent IVF-ET Failures: A Randomized Controlled trial
Maged Ramadan Abou-Saeda; Waleed Hitler El-Tantawy; Kareem Mohammad Labib; Mohamed Abdelfattah Elsenity; Mohammed Mahmoud Samy; Hamed Abdelsadek Aziz Hamed Al-Aarag Faculty of Medicine -Ain Shams University
ABSTRACT
Introduction: The endometrium remodeles throughout the menstrual cycle, and exhibits only a short period of receptivity, known as the “win¬dow of implantation”. The endome¬trium becomes receptive to blastocyst 6-8 days after ovulation and remains receptive for 4 days (cycle days 20-24). Failed implantation remains a significant cause of reproductive failure in both spontaneous and assisted reproduction cycles. Aim of the work: The aim of this study is to determine the effect of Danazol on expression of endometrial αvβ3 integrin in patient with recurrent IVF-ET failures. Patients and Methods: Randomized controlled trial; The current study was conducted at Ain Shams University Maternity Hospital during the period between August 2015 and January 2017; A total of 30 women with previous failed IVF/ICSI trials were included in this study. Results: The current study was conducted at Ain Shams University Maternity Hospital during the period between August 2015 and January 2017. A total of 30 women with previous failed IVF/ICSI trials were included in the study. Conclusion: from this study we concluded that, treatment of patients with recurrent implantation failure with Danazol increases the expression of endometrial αvβ3 integrin which makes the endometrium more receptable for the implanting embryo, thus increases the pregnancy rate.
Key words: CAMP: Cyclic Adenosine Monophosphate; CAMs: Cell Adhesion Mollecules; CC:Clomiphene Citrate; COH: Contolled ovarian stimulation; COX:Cyclooxygenase; cPLA:Cytosolic Phospholipase A