الفهرس | Only 14 pages are availabe for public view |
Abstract The study included 244 men out of 716 men presented to the University hospitals after ethical approval and informed consent. They were allocated into: I- Healthy potent men (n=52) II- Men with erectile dysfunction (ED) responders for sildenafil (n=96) III- Men with ED non-responders for sildenafil (n=96) Inclusion criteria for PDE-5Is non-responders: An inadequate erectile response after 6 attempts using high tolerated dose (200 mg) with manufacturer’s guidelines in respect to time relative to meals, associated medications and sexual stimulation / arousal. Exclusion criteria: Diabetes, smoking, hypertension, dyslipidemia, hypogonadism, cardiovascular disorders, morbid obesity, hepatic or renal failure. They were subjected to: History taking, clinical examination, IIEF-5 questionnaire, estimation of HO-1 GT repeats polymorphisms by PCR. The results were as follows: 1. In ED men, SS genotyping demonstrated significant decrease whereas LL genotyping demonstrated significant increase compared with potent controls. In Summary 88 addition, SL/LL genotyping demonstrated significant increase compared with potent controls. 2. In potent controls, SS genotypes demonstrated significant increase whereas LL genotypes demonstrated significant decrease compared with ED men nonresponders to sildenafil citrate. 3. SL/LL genotyping demonstrated significant increase in ED men nonresponders to sildenafil citrate compared with potent men. 4. In potent men, S allele frequencies demonstrated significant increase whereas L allele frequencies demonstrated significant decrease compared with ED men. 5. In ED men non-responders to sildenafil, S allele frequencies demonstrated significant decrease whereas L allele frequencies demonstrated significant increase compared with potent men and ED men responders for sildenafil. 6. HO-1 genotypes demonstrated significant negative correlation with IIEF-5 and nonsignificant correlation with age. IIEF-5 demonstrated significant negative correlation with age. Conclusion: HO-1 GT repeats polymorphisms play a role of male sexual health being significantly represented in men with ED non-responding for sildenafil citrate. |