الفهرس 
Introduction & Aim of Work
IntroductionOnly 14 pages are availabe for public view
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Abstract
Fluoroquinolones (FQs) are one of the most promising anti-infective chemotherapy. The increasing emergence of resistance to this class of antimicrobial poses a growing threat to human health across the world. One of the most promising effort to decrease the antimicrobial resistance is the use of the nanotechnology. This is the first study to test the mechanisms and selective concentrations of resistance of levofloxacin-loaded nanoparticles and to compare these mechanisms with the unloaded-levofloxacin. This study demonstrated that MICs for levofloxacin-loaded nanoparticle selected mutants were less those of the unloaded- levofloxacin selected mutant when tested with levofloxacin and levofloxacin-loaded nanoparticles. With each selection more mutation appeared in QRDR and AcrAB regulators in unloaded-levofloxacin mutants but not the levofloxacin-loaded nanoparticles mutants.