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Abstract Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder in elderly people; it afflicts an estimated 26.6 million people worldwide, and without a major therapeutic breakthrough, the prevalence of AD is expected to increase to more than 100 million by 2050. The so called “great elderly” patients with numerous co-morbidities, including Alzheimer’s disease (AD) or progressive dementia, are more and more often scheduled to undergo surgery for various pathologies. The main aim is to avoid deterioration of underlying mental diseases, the development of Postoperative Cognitive Dysfunctions (POCD), and the increase of morbidity and hence, the economical cost of patient care. The negative influence of surgery, anesthesia, and care on this category of patients is often underestimated or neglected. |