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Abstract tudy of Neuro- Psychological Complications of Children with BetaThalassemia: Relation to Growth Pattern and Hematological Parameters By Nazif HK1, Moulokhia TK2, Deghidy A3, Azouz HG4 Institute of Post-Graduate Childhood Studies1, Ain- Shams University, Neurosychiatry Department2, Clinical Pathology3 , Pediatrics4, Faculty of Medicine, Alexandria University Introduction Children with thalassemia are vulnerable to neurological, emotional and behavioral problems. Various authors have reported that up to 80% of children with thalassemia are likely to have psychological problems. In thalassemic patients this is a risk factor for noncompliance to treatment.. Aim of The work: The aim of the present study was to detect neuro-psychological disturbances in beta-thalassemic children and to correlate between these disturbances and hematological parameters, growth pattern and pubertal staging of these patients. Subjects and Methods: This cross sectional study was conducted on forty children who are suffering from beta-thalassemia. They have been all subjected to history taking, neurological examination, anthropometric measurement, Laboratory investigations included: complete blood count, Serum ferritin, Serum iron, Serum zinc, total iron binding capacity. Assessment of electroencephalogram (EEG), Intelligent Quotient (IQ) , child behavior assessment using: Child behavior Check List 6-18years (CBCL), Child Manifest Anxiety Scale (CMAS), and Child Depression Invetory (CDI) Results: The mean age in patients was 10.58 ± 2.7 years, 52% of studied patients had normal motor system and 48% had abnormal motor system. 22.5% of patients had immature EEG background activity and 5% had abnormal epileptiform activity. 50% of studied patients had subaverage IQ, 15 % of them had slow learnr. CBCL syndrome items T-score categories in the studied patients showed that boys had a statistically significant higher withdrawn and somatic behavior than girls. Somatic problems had highest percentage of clinical range was (47.5%). 14 (35%) of thalassemic children had clinically abnormal high CBCL total. Abnormal CBCL Internalization problem scores were seen in 55% of children. Clinically significant, abnormal CBCL Externalization score was seen in 11(27.5%) of thalassemic children. 40% of the studied patients had high anxiety grade. 17.5% of the studied patients had moderate depressive manifestations, and 25% had no depressive manifestations. Abnormal motor system examination was related to malnutrition, delayed puberty and high ferritin level. There was significant correlation between hemoglobin with IQ. Immaturity of brain activity was related to lower weight and serum zinc level. There was significant correlation between iron level and CBCL withdrawn depressed complaints, social problems and rule breaking behavior. Attention problems were negatively correlated with Weight z score and BMI z-score while aggressive behavior was negatively correlated with BMIz-score. High CMAS score was related with lower weight, delayed puberty and duration of chelation. High CDI score was related to delayed puberty. Conclusion:. Thalassemia major exerts a dramatic influence on the mental health of affected children.. Height and body mass index as well as serum iron and ferritin are correlated significantly to these problems. Keywords: Beta-thalassemia, neuro-psychiatric, ferritin , growth , iron , CBCL,EEG, IQ, |