الفهرس 
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Abstract
The present study aimed to evaluate the cardioprotective effect of chito-encapsulated polyphenon-60 in nanoformulation (Chito-nanoPP-60) on STZ-induced diabetic cardiomyopathy and attempts to understand the mechanism underlying the effect of this nanoformulation in terms of antiapoptotic and antioxidant ability. Streptozotocin (STZ) was injected into male rats intraperitoneally (40 mg/kg) and after diabetic induction chito-nanoPP-60 (75 mg/kg body weight) was orally administrated for 15 days. Chito-nanoPP-6- with size of 200 nm was prepared by iontropic gelation technique. Chito-nanoPP-60 significantly ameloriated hyperglycemia, HbA1c and lipid fractions level toward the control levels compared with the STZ- treated rats. Chito-nanoPP-60 normalized the increase in the level of troponin T and the activities of CK-MB and LDH in the serum indicating maintenance of heart integrity. This is accompanied with amelioration of the oxidative stress in the heart and considerably minimized the number of apoptotic cells while preventing the increase in the expression of Bax, caspase-3 and 9 and enhancing the expression of antiapoptotic protein Bcl-2.