الفهرس | Only 14 pages are availabe for public view |
Abstract Thirty two patients, 19 female 59.4% and 13 males 40.6% were included in this study, the median age was 45 years (range20-60) all had adenocarcinoma of the rectum. the main presenting symptoms were bleeding per rectum 68.75% followed by constipation 9.4%. Most of our patients presented with T3=46.6% and T4=46.6% Response to preoperative chemo radiotherapy showed that complete response were37%, partial response were 50% and stable disease were 12% With 52.9% of cases that show complete treatment response underwent sphincter conservative surgery, 41.17% of cases that show partial treatment response underwent sphincter conservative surgery and 5.88% cases that show stationary disease underwent sphincter conservative surgery There was significance difference between response and N stage, significance difference between response and T stage and significance difference between response and CEA with (65.6%) of cases with normal CEA, (34.4%) of cases with raised CEA. Significance difference between recponse and overall survival. As regard there was moderate significance difference between recponse and local recurrence. Sphincter conservative surgery was performed in 17 case (53%) while abdomino perineal resection was done in 15 case (47%). All patients tolerate the treatment protocol and neither associated with life threatening events nor grade3 or4 toxicity. |