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Abstract The study aimed to investigate the effect of different levels of green and dried coriander on serum glucose, lipid profile, kidney functions, liver enzyme activities and histopathological examination of liver in diabetic rats. Forty-eight albino rats weighing (200 ± 10 g.) were divided into two main groups; the first group (6 rats) fed on basal diet (NC) and the second group (42 rats) was treated with 150 mg alloxan /kg body weight to induce diabetes. After two days serum glucose determined in all rats to insure the induction of diabetes. Then the second main group was divided into seven groups. As follow group (1) fed on basal diet as a positive control group (PC). Groups (2&3) fed on diet containing 1 % green coriander and coriander seeds, respectively; groups (4&5) fed on diet containing 3% green coriander and coriander seeds, respectively. And groups (6&7) fed on diet containing 5% green coriander and coriander seeds, respectively. Results indicate that, serum glucose total cholesterol, triglycerides, low and very low density lipoprotein-cholesterol, AST, ALT, uric acid, urea nitrogen and creatinine were elevated in the positive control group (PC). Feeding diabetic rats on diet containing some levels from green coriander or coriander seeds improved total cholesterol, triglycerides, LDL-c, HDL-c, VLDL-c, AST, ALT, uric acid, urea nitrogen and creatinine, specially (at high level). In conclusion, the present results indicated that the most effective treatment was observed with green and dried coriander received at high level. |