الفهرس 
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Abstract
Background: Rheumatoid arthritis is known as chronic and an autoimmune disease has many effects on bone healing. Platelet rich fibrin has jelly-like consistency, contains large amount of fibrin, platelets and leukocytes and has many advantages like osteoinductivity, osteoconductivity, osteogenesis and high success rate in many clinical uses. Aim of the study: It was aimed to evaluate the impact of platelet rich fibrin on bone healing of rheumatoid arthritis. Materials and Methods: 80 adult female albino rats were used. The animals were classified into two main groups, (control and rheumatoid groups), forty rats for each group: Control group (subdivided into subgroup I and subgroup II), and rheumatoid group (subdivided into R subgroup I and R subgroup II), all groups were subjected to surgical bone defect in the submental area of the mandible, control subgroup I, R subgroup I without using platelet rich fibrin graft materials. But Control subgroup II and R subgroup II group with using platelet rich fibrin graft material in bone defect. The rats of each groups were sacrificed after (4, 10, 15 and 30) days and examined using light microscope. Haematoxyline and Eosin, Masson’s trichrome and immunohistochemical staining were used. Results: the histological examination showed that the bone healing was enhanced in the samples treated with platelet rich fibrin in normal and rheumatoid arthritis and increased with increasing the periods of time. Conclusions: from the results of the present study, it could be concluded that the platelet rich fibrin enhanced bone matrix formation and maturation of bone trabeculae during bone healing in normal and rheumatoid arthritis of albino rats.