الفهرس 
INTRODUCTION & AIM OFTHEWORKOnly 14 pages are availabe for public view
 |  | from | 256 |  |  |
| | | from | 256 | | |
Abstract
Two kinds of fish oils were extracted from wastes of fish canning factories in Esmailia and Aswan, purified, esterified and subjected to GLC analysis. Both fish oil esters exhibited high contents of ro-3 fatty acids.
The protective effect of fish oil esters was studied by feeding hamsters on a hyperlipidemic diet and ingesting them concomitantly with fish oil esters. Evaluation of the therapeutic effect of fish oil esters was extensively studied by ingesting hyperlipidemic hamsters with ethylated fish oil esters during feeding either hyperlipidemic diet or normal diet. The fish oil esters were ingested each 2 days for 3 successive weeks.
Biochemical studies were carried out on lipid panems, some liver function tests (ALP, AST and ALT) and glucose, and the results were compared with that of the untreated hyperlipidemic hamsters.
Results showed significant decreases in the tested serum parameters (TL, TC, TG, LDL-C and TCIHDL-C) and ”liver parameters (TL, TC, TG, FC, CE and PL) in hamsters ingested with fish oil esters and fed on hyperlipidemic diet as compared to untreated hyperlipidemic hamsters.
When hyperlipidemic hamsters were fed on normal diet and ingested with the fish oil esters, significant decreases were observed in the above tested serum and liver parameters.
Glucose and glycogen content also showed substantial decreases.
Histopathological studies on various arteries of hyperlipidemic hamsters showed variable decreases in the thickness of arteries when the hamsters were ingested with either fish oil esters or EPA capsule.
In conclusion, fish oil were found to have protective and therapeutic effects against hyperlipidemia in hamsters.