الفهرس | Only 14 pages are availabe for public view |
Abstract A number of new 2–methylbenzimidazole derivatives were synthesized and structural elucidation of the compounds was performed by IR,1H-NMR and Mass spectroscopic data . Studies and researches have shown, that derivatives of 2–methylbenzimidazole and its own nucleosides have biological activity against gram-negative and gram-positive bacteria, which infect humans and animals and its medical uses became act as a remedy against these types of bacteria. Sugar hydrazones, N-substituted acyclic nucleoside analogues and arylidene derivatives bearing imidazole were prepared showed mild to high activity against the tested organisms (staphylococcus aureus, micrococcus, salmonella typhi, salmonella para typhi, Escherichia coli, aspergillus flavus, aspergillus fumigates, aspergillus ochraceus and candida albicans),they showed antibacterial and antifungal activities. Synthesis of new compounds of these families with the effectiveness of high biological and fewer side effects take our attention. The starting compound 2–Methylbenzimidazole (171) was prepared from o-Phenylenediamine (170), Acetic acid and in presence of water under reflux. The compound 171 was allowed to react with ethylchloroacetate in dry acetone and in the presence of anhydrous potassium carbonate to afford 1-ethoxycarbonylmethyl-2- methylbenzimidazole (172). Treatment of 172 with hydrazine hydrate in ethanol under reflux gave the corresponding hydrazide 173 in 83 % yields (scheme 3). |