الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
The present investigation comprises a survey covering the chemistry and the
biological activities of some compounds containing the indole ring system.
In this work, diclofenac sodium was used as a precursor to obtain
compounds with higher activity and selectivity towards COX-2 enzyme.
Acid catalyzed cyclization for diclofenac sodium used to obtain the indole
ring.One known and five novel intermediate compounds were prepared, in
addition to twenty nine novel final compounds, a detailed discussion of the
experimental results attained is presented with an adequate interpretation.
The new compounds were subjected to a molecular modeling simulation
study using Molegro Virtual Docking software (MVD), to predict their antiinflammatory
activity and selectivity towards COX-2 enzyme.
Finally, all final compounds were subjected to in vivo evaluation of
analgesic activity using acetic acid induced writhing method, and antiinflammatory
activity using carrageenan induced paw edema, as well as
ulcerogenicity via oral administration of test compounds, the results revealed
that compounds V1, V5, V10, VI1, VI5, VI6, VI8, VI9, VI11, VIII2, IX2, and IX4
were the most active.