الفهرس 
General Human nutrition
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Abstract
HSC transplant patients are likely to develop a series of
metabolic disorders of varying severity, mostly during the
immediate post-transplant period. The main causes are the
adverse effects of the conditioning regimen itself, the
immunosuppressive drugs (to control or for prophylaxis of
GVHD) and the total parenteral nutrition (TPN), which may
increase the risk of opportunistic infections and inflammatory
processes.
The aim of this study was to Assess nutritional status in
patient undergoing Allogeneic Haematopoietic Stem Cell
Transplantation to decrease morbidity and mortality rate and
improve quality of life.
The study was conducted on 50 patients who had
allogeneic HSCT at Ain Shams bone marrow transplantation unit.
Results were as follow :
There was significant difference in BMI at day 30 and day
180 in comparison to baseline,( p value <0.001). In contrast there
was insignificant difference in BMI at day 180 in comparison to
day 30,(p value = 0.075). There was significant difference in laboratory variables
(sodium ,potassium, magnesium , phosphate , calcium , albumin ,
and hemoglobin at baseline , day 30 and day180 range (<0.001
and 0.002 respectively). in contrast , there was insignificant
difference in total protein (p value = 0.252).
Significant univariate analysis for global SGA at day 30
was comorbidity ,(p value <0.001),fever duration more than 1
week,( p value = 0.004), and fungal infection more than 1 week ,(
p value = 0.045). Also , there was significant univariate analysis
for global SGA at day 180 was comorbidity ,( p value = 0.001),
diagnosis ,(p value = 0.023) ,fungal infection more than 1week ,(
p value = 0.025) and ≥ grade II acute GI GVHD ,( p value
<0.001).
Significant multivariate analysis for global SGA at day 30
was comorbidity ,( p value = 0.002), and fever duration more than
1 week ,( p value = 0.012).Also there was significant multivariate
analysis for global SGA at day 180 was comorbidity ,( p value= 0.
044), diagnosis ,( p value =0.036 ), and ≥ grade II acute GI
GVHD ,(p value = 0.010).
The main risk factors of malnutrition were comorbidity ,
fever duration more than 1 week ,fungal infection more than 1
week , ≥ grade II acute GI GVHD and diagnosis (SAA and acuteleukemia was a significant risk factor for malnutrition. This can
be attributed to the more frequent occurrence of GI symptoms
lasting for > 1 week than other diagnosis).