الفهرس 
LipoproteinsOnly 14 pages are availabe for public view
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Abstract
Norplant implant system 1s becoming widely used contraception as a long term reversible progestogen
only contraception system (Singh and Ratnam, 1997). This system consists of 6 silastic capsules
containing levonorgestrel which is the active isomer of the norgestrel, one of the members of the
family 19 nortestosterone which has residual androgenic activity (Speroff et al., 1999). Because
of its androgenic activity and also the potent antiestrogenic activity as it is expected to lower
HDL cholesterol (Fotherbay, 1984).
Recent studies shows that total triglycerides (TG), cholesterol and low density lipoprotein
cholesterol (LDL-c) were decreased through five years of Norplant use. High density lipoprotein
cholesterol (HDL-c) showed a significant increase in the first year followed by decrease over the
years to its preinsertion level (Singh et al., 1989, 1992),
Other studies show that total serum TG and cholesterol were reduced during the use ofNorplant while
HDL cholesterol was significantly reduced following six months of Norplant use. At twelve months,
the value improved but it was sill significantly decreased when compared to preinsertion value
(Otubu et al., 1993). Singh et al. (1993) have reported that total cholesterol, LDL cholesterol and
total TG continued to remain below the preinsertion mean at six months post removal but HDL cholesterol showed a significant increase following
removal of Norplant.
The strong inverse relation between HDL-c concentration
and coronary heart disease (CHD) risk is well established by
observational epidemiologic studies. Each 1-mg/dL increment
in HDL-c is associated with a 2% risk decrement in men and
3% risk decrement in women of CHD (Ass mann et al., 1998).