الفهرس 
ElectrocardiographyOnly 14 pages are availabe for public view
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Abstract
This was a prospective study conducted on 22 patients, who were
referred for elective hemodynamic study due to PAH secondary to CHD in
Ain Shams University Hospitals over a period of 30 months, between March
2012 and July 2014. Sildenafil affected functional class and there was
improvement in 9 patients. PVR decreased in ten patients and successfully
performed total repair while on sildenafil therapy in one patient. PVR
increased in 6 patients and no change occurred in one patient with
DILV&VSD (Taussing Bing anomaly). While four patients died on
sildenafil therapy.There were statistically significant increase in PA oxygen
saturation 92.9 % compared to 80.3 % in cases with increased PVR after oral
sildenafil therapy (p value 0.002), aortic oxygen saturation increased
significantly 99.2% compared to 82.4% in 2nd group (p value 0.004),
pulmonary blood flow Qp 9.5 (L/min/m2) compared to 3.4(L/min/m2) (p
value 0.002). Sildenafil was well tolerated, and no patients withdrew. There
was no change in creatinine,urea,liver function tests,or platelet count. There
were no significant change in systemic blood pressure, pulmonary blood
pressure, PVR, SVR, left and right atrial pressures, superior vena caval
oxygen saturation and hemoglobin in cases before and after treatment with
oral sildenafil. In this study,sildenafil affected functional class and not
hemodynamics . Whether or not longer term use of sildenafil therapy will
lead to actual improvement in the hemodynamic parameters and reduction in
PVR remains a question that needs longer term follow up in larger patient
groups.