الفهرس 
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Abstract
Cirrhosis is the end result of chronic liver injury from a variety of
causes and it was found that hyponatremia is a common abnormal finding
in approximately 57% of hospitalized patients with chronic liver disease
and in 40% of the outpatients with liver disease.
The aim of the present work is to study the correlation between serum
sodium level and the severity of complications in liver cirrhosis.
100 patients were enrolled in the study ,75 patients of them with liver
cirrhosis and 25 patients served as control, Patients with liver cirrhosis
randomly selected from Mahala El-Kubra hospital based on severity of
complications at the time of admission , Patients with hepatocellular
carcinoma presented on admission and during the follow up, also patients
using diuretics within 1 month before admission or taking antiviral drugs
were excluded.
Liver function tests, serum sodium and potassium, CBC, viral markers,
abdominal ultrasound, Child- Pugh scoring were done.
Patient were classified into groups according the previous Child Pugh
classification as 25 patients were Child-Pugh A, 25 were B and 25 were
C, while in the control group 25 persons.
Assessing serum sodium profile among the two groups revealed a
highly significant difference between the two studied groups in all the
previous parameters (P < 0.001) and revealed the following facts:
• As regards serum sodium difference between control and
cirrhotic group it was found that the difference between the 2
groups is statistically highly significance p value < 0.001
SUMMARY
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• As regards the decrease in serum sodium level in relation to
the child classification it was found highly significant
correlation p value <0.001
• As regards the decrease in serum sodium level in relation to
the degree of ascites, there was strong correlation, P value
<0.001, which is found to be highly significant correlation.
• As regards the decrease in serum sodium level in relation to
the incidence of pleural effusion, there was no significant
correlation, P value >0.05
• As regards the decrease in serum sodium level and SBP,
there was significant correlation, P value <0.05
• As regards the decrease in serum sodium level and the
degree of encephalopathy, there was significant correlation,
P value <0.05
• As regards the decrease in serum sodium level and the HRS,
there was no significant correlation, P value >0.05
• As regards the decrease in serum sodium level and degree of
esophageal varices, there was strong correlation, P value
<0.001, which is found to be highly significant correlation.
It is therefore concluded that Hyponatremia, especially serum levels
<130 mmol/L, may indicate the existence of severe complications
associated with liver cirrhosis.