الفهرس | Only 14 pages are availabe for public view |
Abstract Thirty adult albino rats were used in the present study to evaluate the possible role of natural antioxidants (GSE) on expermintaly induced gastric ulcer by acetyle salicylic acid. They were divided into five main groups: Group I (Control group): consisted of 10 rats. They were further subdivided into: -Subgroup Ia (negative control): consisted of 5 rats. They were kept without any treatment and served as control for all experimental groups. -Subgroup Ib (positive control group): consisted of 5 rats. Each rat was received a single dose of 3 ml of 1% carboxymethyle cellulose dissolved in distilled water. Group II (GSE group): consisted of 5 rats, they received GSE in a dose of 250 mg/kg/day orally by gavage for 10 days. Group III (Aspirin induced gastric ulcer group): consisted of 5 rats. They were fasted 24 hours then received a single dose of 300 mg/kg BW of aspirin dissolved in 3 ml of 1% carboxymethylcellulose orally by gavage. GroupIV (GSE treated group): Consisted of 15 rats. They were further subdivided into three subgroups: Subgroup IVa: consisted of 5 rats. Each rat received GSE in a dose of 250 mg/kg/day orally by gavage for 10 days. One hour after administration of the last dose each rat received a single dose of aspirin. |