الفهرس 
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Abstract
This study was carried out to evaluate the possible effect of low level laser therapy (LLLT) on radiation induced oxidative stress in rats’ salivary glands. Material and Methods: Sixty four male Albino rats were divided into two groups. One group where the left parotid gland was exposed to 3 sessions of LLL, then rats were subjected to 3 sessions of whole body gamma-radiation. In the other group, rats were subjected to 3 sessions of gamma-radiation; each was followed by a session of LLL to the left parotid gland. The right gland of both groups was used as irradiated control. Parotid glands were collected 1day, 3days, 1week. and 2weeks after the end of treatment and were subjected to histological examination and immunohistochemical analysis. Results: The parotid gland of both laser groups showed less intracytoplasmic vacuolization, slight alteration of acinar architecture and almost even size nuclei as compared tohe irradiated gland. LLL either before or parallel to gamma-irradiation was ffective in increasing cell proliferation on the third and seventh day, espectively as compared to the gamma irradiated group (P<0.05). Statistically, results revealed significant decrease in optical density ofcaspase 3 activity in the lased groups on the first week as compared to the control.Conclusion: LLLT attenuates the harmful effect of gamma irradiation on the parotid glands of the rats. Also, it improves gland regeneration through modulation of cell proliferation and apoptosis.