الفهرس | Only 14 pages are availabe for public view |
Abstract There is renewed interest in magnetic and plasmonic photo-thermal hyperthermia, as a cancer treatment method. In the current study, super paramagnetic iron oxides nanoparticles, gold nanospheres and gold-iron oxide core shell nanoparticles were prepared and characterized for inducing hyperthermia to treat subcutaneous Ehrlich carcinoma implanted in female Swiss albino mice through three treatment techniques (Magnetic, Optical and Magneto-Optical) resonance hyperthermia .The maximum temperatures achieved in the tumors were 45±2.0°C, 50±1.5°C, 58±2.0°C, respectively. The results revealed that, all mice treated by the first two techniques, the tumors were still as the same as before the treatments, as well as the rate of tumors growth were very slow if compared with the control mice. In contrast more than 50% of the mice treated with the third revealed a complete disappearance of the tumor. So, this simple, non-invasive method shows great promise as a treatment technique for clinical setting. To our knowledge, tow papers from this thesis were published recently in International Magnetic Resonance Imaging journal and International Nanomedicine journal. The third one is submitted to be published in Magnetism and Magnetic Material journal. |