الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 32 |  |  |
| | | from | 32 | | |
Abstract
The present study evaluated the antidepressant-like effect of pomegranate by using reserpine-induced experimental model of depression in rat. Fluoxetine was used as a reference anti-depression drug. Daily administration of reserpine for 14 days significantly increased the immobility time forced swimming test (FST) indicating the occurrence of depression, with minor motor dysfunction. Thereafter, daily administration of pomegranate juice at a dosage of 3ml/kg of body weight/day for 14 and 28 days significantly reduced the immobility time in forced swimming test (FST), indicating that pomegranate has antidepressant-like activity. Reserpine caused remarkable decrease in monoamines (NE, DA and 5 -HT) in both brain cortex, midbrain and brainstem. Whereas both pomegranate and fluoxetine had a restorative effects on brain monoamines. The results of the present study suggest that pomegranate exerted its antidepressant-like activity probably by rebalancing the monoaminergic neurotransmission in brain.