الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Nature has been a source of medicinal treatments for thousands of years. Resveratrol is one of the natural products which has antioxidant activity. The main objective of this study is to evaluate the biological effects of dietary resveratrol in hyperlipidemic and alloxan-induced diabetic rats, using fifty-four adult male albino rats, weighting 150-160 g were divided into three main groups. Rats were divided into the following groups: group 1: Negative Control Group- normal group- (6 rats). In this group rats were kept on basal diet and tap water (untreated group). group 2: induced diabetic group (24 rats). This group were divided into (4) subgroups each of them (6) rats, as following: A) Positive control group: Diabetic rats were fed on standard diet during the study period. B) Diabetic rats fed on standard diet + dietary resveratrol (5 mg/kg BW). C) Diabetic rats fed on standard diet + dietary resveratrol (10 mg/kg BW). D) Diabetic rats fed on standard diet + dietary resveratrol (20 mg/kg BW). ENGLISH SUMMARY 14 5 group 3: induced hyperlipidemic group (24 rats). This group were divided into (4) subgroups each of them (6) rats, as following: A) Positive control group: hyperlipidemic rats fed on standard diet along the study period. B) Hyperlipidemic rats fed on standard diet and administrated 5 mg/kg BW orally of dietary resveratrol. C) Hyperlipidemic rats fed on standard diet and administrated 10 mg/kg BW orally of dietary resveratrol. D) Hyperlipidemic rats fed on standard diet and administrated 20 mg/kg BW orally of dietary resveratrol. At the end of experiment (4 weeks), the blood samples were collected after 12 hours fasting and serum was separated for determination of: • Lipid profile Cholesterol, tri-glycerides (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), very low density lipoprotein (VLDL-C), Atherogeric index, urea, creatinine, uric acid, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and alkaline phosphatase (ALP), GOT/GPT ratio, glucose, albumin, globulin, total protein. • At the same time, the organs: heart, kidney, liver, lungs and spleen were removed, washed in saline solution, dried by filter paper, weighted, and stored frozen in formalin solution 10% for histopathological examinations. ENGLISH SUMMARY 14 6 The obtained results can be summarized as following: 1- Effects of dietary resveratrol on the diabetic rats. The effect of dietary resveratrol on BWG%, FI, and FER of diabetic rats: Body weight gain (BWG %) All diabetic rats, treated with different doses of RV, were significantly lower as compared to control (+). The best BWG% was recorded for group 4 (diabetic rats fed on RV 10 mg) when compared to control (-) group. Food Intake (FI) All diabetic rats, treated with different doses of RV were lower when compared with control (+) but this reduction without any significantl differences. Statistically, the best FI was recorded for group 3 (diabetic rats treated with RV 5 mg) when compared to control (+) group. Food Efficiency Ratio (FER) All diabetic rats , treated with different doses of RV, showed significant decreases in mean values as compared to control (+) group. Statistically, the best FER was recorded for group 3 (diabetic rats treated