الفهرس 
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Abstract
This study was conducted to evaluate laminin-5 expression in OSCC and to investigate the possible correlation that might exist between laminin-5 expression and different grades of OSCC.
Thirty cases of OSCC were selected, and classified according to degree of differentiation into 14 well differentiated, 12 moderately differentiated and 4 poorly differentiated. Using peroxidase- antiperoxidase method for immunohistochemical examination, each specimen was stained with laminin-5 antibody.
For result interpretation, a quantitative assessment of laminin-5 antibody expression was carried out using the image analysis software (Germany, Software Leica Qwin 500).
Statistical analysis of the present study regarding laminin-5 expression in different grades of OSCC revealed a significant statistical difference between well differentiated, moderately differentiated and poorly differentiated cases of OSCC (p<0.001). These results mean that the expression of laminin-5 decreased when the aggressiveness of OSCC increased, the degree of differentiation decreased and adhesion between cells decreased. These data suggested that laminin-5 is a reliable marker for differentiating different grades of OSCC.
Therefore, the expression of laminin in the BM may be a useful parameter to evaluate tumor histologic differentiation and aggressiveness.