الفهرس 
List of abbreviationsOnly 14 pages are availabe for public view
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Abstract
Introduction:Asthma is a polygenic, multifactorial disorder, which means that many factors contribute to its development. These factors are both genetic and environmental.CTLA-4 gene is located on chromosome 2q33. It contains several Single Nucleotide Polymorphisms (SNPs) which have been linked to susceptibility to autoimmune disease as asthma.Aim of the work:The aim of the current study is to explore the relation between different CTLA-4 gene polymorphisms and serum IgE in bronchial asthma (atopic and non-atopic). Subjects and methods:10 ml blood was withdrawn from each individual of the study, and divided in 2 tubes:a)5 ml on EDTA used for DNA extraction, PCR amplification and separation by gel electrophoresis.b) 5 ml used for measurement of IgEResults:CTLA-4 gene C/T 60 polymorphisms conferred susceptibility to bronchial asthma