الفهرس 
Pressor ResponseOnly 14 pages are availabe for public view
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Abstract
The stress response results from the increase in sympathetic and sympathoadrenal activity, as evidenced by increased plasma catecholamines concetrations in patients undergoing surgery under general anesthesia.Various drug regimens and techniques have been used from time to time for attenuating the stress response to laryngoscopy and intubation, including opioids, barbiturates, benzodiazepines, beta blockers, calcium channel blockers, vasodilators, etc(3,4). The dose of opioids required for effective attenuation of stress response is fairly high and numerous drugs have been used as adjuncts in decreasing the dose of opioids with a varied level of success, but are not absolutely free from side effects (4,5). Dexmedetomidine, the pharmacologically active d-isomer of medetomidine, is a highly selective and specific α2-adrenoceptor agonist (6). It differs from clonidine in being 16 times more specific for α2-receptors. Dexmedetomidine, by its central sympatholytic action, promotes hemodynamic stability when used as an adjuvant during general anesthesia. It has analgesic andanesthetic sparing property (7). Dexmedetomidine has potent sedative properties (8-9). However, because of its sedative property, it is unknown if the recovery from anesthesia would be delayed when used as continuous infusion (10).