الفهرس | Only 14 pages are availabe for public view |
Abstract Hypertension and atherosclerosis represent the public diseases of the modern world, affected increased average of population and contributed to cardiovascular diseases, renal failure and cirrhotic liver. Eighty fertile male and virgin female of albino mice (mus musculus) (at a ratio of 1 male to 3 females) weighing approximately 25g body weight used in the experiment. The hepatocytes possessed different abnormal cytological alterations, including fatty change and vacuolar and ballooning degeneration in histological investigations. Experimental atherosclerotic mothers with or without hypertension possessed micro- and macrovesicular steatosis and moderate fibrotic change. In kidney, experimental atherosclerotic group revealed marked dilation of the proximal convoluted tubules with slogging of almost entire epithelium due to desquamation of tubular epithelium, intense glomerular hypercellularity. Also in heart, experimental atherosclerotic group showed marked alterations of the muscle fibers, the foetal blood vessels become collapsed and engorged with blood cells. The fibers appeared widened and infiltrated by densely grouping leukocytes. In experimental hypertensive groups with or without atherosclerosis, there was a detected degeneration of myocardial muscle fibers. There was marked increase of heat shock protein 70 (HSP70), 8-hydroxy-2-deoxyguanosine(8-OH2-dG), caspase 3 & 7 (CASP3&7) and thrombomodulin (TM) in hepatic , renal and myocardial tissue. The genomic expression of the degree of laddering (total DNA fragmented) increased in liver, kidney and heart of mother mice subjected to either atherosclerosis or hypertension or combined treatment. |