الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Endometrial hyperplasia (EH) is a common diagnosis (5–10%) in women presenting with abnormal uterine bleeding, and can progress to cancer if left untreated. The aim of this work is to investigate the gene polymorphism of CCND1 A870G, and LT-α A252G and its association with the risk of simple endometrial hyperplasia (SEH) among Egyptian population and to evaluate the diagnostic value of some biochemical markers such as CA 125 and HE4. The following results were obtained: 1. Patients had significantly higher levels of serum CA 125 and HE4 compared to the controls. 2. HE4 had a higher sensitivity and specificity compared to CA125 and more accurate in simple endometrial hyperplasia diagnosis. 3. The genotype distribution of the CCND1 polymorphism in SEH cases showed an increased frequency of A allele, and increased the frequency of AA genotype in patients versus controls. 4. The genotype distribution of the LTα A252G polymorphism in SEH cases showed an increased frequency of A allele, and increased the frequency of AA and GA genotypes in patients versus controls. 5. The relationship between CA 125 and HE4 biomarkers and genotype of CCND1 showed that, both CA 125 and HE4 showed a significant increase in SEH cases compared to the control in case of AA and GG genotypes. 6. The relationship between CA 125 and HE4 biomarkers and genotype of LT-α A252G showed that both CA 125 and HE4 showed a significant increase in SEH cases versus controls in case of GA genotype.