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العنوان
Biochemical Study on The Role of Certain Natural Products on cholesteryl Ester Transfer Protein Activity in Hyperlipidemic Rabbits /
المؤلف
Elnagar, Gehad Mohamed Abd-ELHady.
هيئة الاعداد
باحث / جيهاد محمد عبد الهادى
مشرف / محمد محمود السويدى
مناقش / عاطف تادرس فهيم تادرس
مناقش / ممدوح محمد الشيشتاوى
الموضوع
Natural Products- therapeutics. cholesteryl Ester Transfer Protien.
تاريخ النشر
2014.
عدد الصفحات
v.p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
العلوم الصيدلية
الناشر
تاريخ الإجازة
1/1/2014
مكان الإجازة
جامعة الزقازيق - كــليـــة الصيدلــــة - department of Biochemistry.
الفهرس
Only 14 pages are availabe for public view

from 200

from 200

Abstract

Hyperlipidemia and its subsequent complications represented by
atherosclerosis risk and CVD are major threat to global public. It is a silent
killer as the patient does not know its progression since started many years
ago even from childhood years.
The present work aimed mainly to:
1- Discuss the effect of hyperlipidemia induced in rabbits on many
biochemical and histological parameters.
2- Investigate athero-protective effect of 10-dehydrogingerdione, a
natural component isolated from Zingiber Officinale, related to its
CETP inhibitory activity as a new strategy for treatment,
additionally natural products namely ginger and curcuminoid
extracts.
To fulfill such objectives, the following parameters were selected to be
studied:
1- Serum:
 Total cholesterol (TC), TG, HDL-C and CETP mass.
2- Visceral WAT:
 Leptin content.
3-Liver tissues:
 MDA content.
 Gene expressions of apo A-I, apo A-II, apo B and CETP.
This was followed by histopathological study for aortic sections to
illustrate general structural changes in aortic tissues using H&E.