الفهرس 
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Abstract
Mean platelet volume (MPV) is a measure of the average size of circulating platelets and can provide clues to the kinetic mechanism of an infant’s thrombocytopenia (Baer et al., 2009).
Changes in MPV may be a marker of platelet production as well as an indicator of change in severity of several disease states such as sepsis, thrombosis, NEC or even RDS (Yurdakök et al., 2012).
Our aim in this study was to measure the level of MPV in some neonatal disorders including (Neonatal sepsis, Respiratory distress syndrome, Necrotizing enterocolitis and Neonatal jaundice) in preterm and full term neonates.
This study included 159 neonates stratified into five groups: Neonatal sepsis group (46 neonates), Respiratory distress syndrome group (43 neonates), Necrotizing enterocolitis group (10 neonates), Neonatal jaundice group (20 neonates) and control group (40 neonates).
All neonates included in the study were subjected to history taking, complete clinical examination, as well as laboratory investigations including Complete blood count including MPV, Total and direct serum bilirubin levels for jaundiced neonates, CRP and blood culture for septic neonates, plain x-ray on chest for RDS neonates and plain x-ray erect on abdomen for NEC neonates.
Our study showed that:
* There was a significant difference between Neonatal sepsis and control groups as regard to Hb, TLC, platelets and MPV, with non significant difference between +ve and –ve culture of septic group as regard to platelet count and MPV.
* There was a significant difference between RDS and control groups as regard to MPV.
* There was a significant difference between preterm NEC group and preterm control group as regard to platelet count and MPV.
* There was a significant difference between Neonatal jaundice and control groups as regard to Hb, with non significant difference as regard to platelet count and MPV.
* There was a significant difference between pretem and full term neonates in RDS group as regard to MPV, with non significant difference in NS, NJ and control groups.
* There was a significant difference between preterm and full term controls as regard to TLC and platelet count, with non significant difference as regard to MPV.
* There was a negative inverse significant correlation between platelet count and MPV as regard to NS( moderate correlation) ,NEC( strong correlation) and RDS( fair correlation), with negative non significant correlation between platelet count and MPV in Neonatal jaundice group and in control group.