الفهرس | Only 14 pages are availabe for public view |
Abstract Summary Ectopic pregnancy occurs in about 1% of pregnant women, it is the leading cause of maternal mortality in the first trimester. The classic triad of symptoms of ectopic pregnancy includes abdominal pain and vaginal bleeding after a period of amenorrhea. These are nonspecific findings that are also present in threatened or spontaneous abortion. The most common gestational age at time of diagnosis is 6 to 10 weeks, but ectopic pregnancy can be discovered until time of delivery. The purpose of this study is to evaluate maternal serum level of Inhibin A in cases diagnosed as Ectopic pregnancy and to compare it with participants showing normal intrauterine pregnancy and others normal non-pregnant females, and to determine the possibility of its clinical use as an endocrine marker for differentiating ectopic pregnancy from early viable intrauterine pregnancy by means of a single test. This study was carried out in Daraw hospital and Aswan teaching hospital after the approval of the Research Ethics Committee, during the period between may 2013 and may 2014. This study was conducted on 45 women who had been divided into 3 groups; Group A: Included 15 non-pregnant females at the reproductive age group. Group B: Included 15 women with normal asymptomatic spontaneously conceived intrauterine pregnancy at the gestational age of 8-12 weeks; And finally Group C: Included 15 pregnant females diagnosed as ectopic pregnancy by ultrasound examination and laboratory investigations. All participants were subjected to: complete history taking including the last menstrual period (L.M.P) for estimation of the gestational age, complete physical and clinical examination and ultrasound examination. We found that Inhibin A had 100% sensitivity and specificity for EP compared with vIUPs. Thus, it could be used reliably to distinguish between EP and vIUPs |