الفهرس 
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Abstract
Procalcitonin is the precursor for the hormone calcitonin (CT), which is found in the thyroid C cells and the pulmonary endocrine cells, it has a metabolic role in calcium homeostasis.
In normal subjects, PCT is found in the blood at a very low concentration but during bacterial infection, there is more than 1,000 fold increase in its blood concentration as it is released by many other tissues as Liver, Spleeen and Lungs.
Liver transplantation is an operation to remove a diseased or damaged liver from the body and replace it with a healthy one.
Liver transplantation is indicated in several conditions as: Acute liver failure, chronic liver disease, Viral Hepatitis, Cholestatic liver diseases, Hepatic malignancy, Metabolic diseases and vascular disorders.
There are many contra-indications for Liver Transplantation as: Severe Cardio pulmonary disease, Patients with active Alcohol or substance abuse, patients with old age , Morbid obesity, HIV infection and presence of other untreated infections and Lack of compliance of the patient.
Complications of Liver transplantation are mainly Rejection and Infections.
Acute rejection is defined as ‘‘inflammation of the allograft, elicited by a genetic disparity between the donor and recipient. It is manifested by Abdominal pain, tenderness around the liver or swelling can be signs of liver rejection, ascites may also occur in the abdomen. It is accompanied by elevated liver Enzymes, elevated Bilirubin, Leucocytosis and Esinophilia. Also, core niddle biopsy is needed to confirm the diagnosis and to determine the severity of rejection.
Acute rejection is treated by one or multiple few stratiges: By a short course of high dose Corticosteroids and repeated again. Or Triple therapy which adds Cacineurin Inhibitors and Anti proliferative agents.
Infection after transplantation is affected by the intensity of immunosuppression .
Infection may occur at the early post transplantation period and it is either donor derived or recepient derived, but at the intermediate post transplantation period, it is usually opportunistic infection, also, it may occur at the late post transplantation period and it is usually community acquired pathogen.
PCT is used as a biomarker for sepsis as it increases 3 to 4 h after infection ,reaching its peak after 6h and plateau for 24h and has a half life of about 25 to 30 h.