الفهرس 
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Abstract
Serum Acertylcholinesterase (BuChE) is synthesized by the liver immediately released into the plasma. Serum BuChE is used in gastroenterology as an indicator of liver synthetic capacity and patients with decreased serum BuChE have a poor prognosis. Serum BuChE activity is reduced in liver dysfunction due to reduced synthesis, so we determine the serum cholinesterase activity at different liver diseases levels, using three groups of serum samples, 57 patients with liver disease. The study population consisted aged between 20 and 65 years with mean± (53), 33 male and 24 female. First group was 19 cirrhotic serum sample, second group was 20 fibrotic serum sample and third group was 18 fatty liver serum sample and 20 blood samples from normal subjects. The following parameters were assayed serum level of cholinesterase, serum ALT and AST levels, serum total bilirubin level, serum alpha fetoprotein (AFP), prothrombin time, platelet count,serum albumin level, micro RNA.
In total, liver infected samples (n= 57), gave us significant results, the median of results were varied among the groups where (P < 0.0001) for ChE between fatty liver, cirrhosis, (P < 0.0001) for ChE between fibrosis , cirrhosis and (P = 0.0496) for ChE between fibrosis, fatty liver.
The results we have obtained reflect that serum cholinesterase enzyme has statistically significant difference between the mean of liver disease subjects and healthy controls. These results suggest that the determination of serum cholinesterase activity is a cost-effective diagnostic enzyme as marker of chronic liver disease.