الفهرس 
Down SyndromeOnly 14 pages are availabe for public view
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Abstract
Aim of study: The present study was designed to evaluate the bone mineral density of children with Down syndrome and compare it with a healthy age and sex matched control group.
Subjects: The present study was conducted on 60 Down syndrome children aged 6 to 18 year and 20 healthy children of the corresponding age group.
Methods: All children were subjected to:
1- Full history including:
Assessment of daily dietary calcium intake through Food Questionnaire.
Assessment of duration of sunlight exposure (hours per week).
2- Physical examination including:
General and systemic examinations.
Measurement of weight and height and calculation of BMI
3- Blood samples were collected for estimation of serum levels of calcium, phosphorus and alkaline phosphatase enzyme.
4- Assessment of lumbar spine BMD and left femoral neck BMD by DEXA.
Results: The children with DS have a reduced BMD in comparison with controls.
The mean value of lumbar spine BMD of Down syndrome children was 0.58 ± 0.17 g/cm², and that of non Down syndrome was 0.69 ± 0.18 g/cm².
The mean value of femoral neck BMD of Down syndrome children was 0.68 ± 0.17 g/cm², and that of non Down syndrome was 0.76 ± 0.14 g/cm².
There is significant difference between case and control groups in lumbar spine BMD. However, there is no difference found between the two groups as regard femoral neck BMD.
There are highly significant positive correlations between lumbar spine and femoral BMD and each of age, dietary calcium intake, weight, height and body mass index and negative correlation with alkaline phosphatse enzyme.
There are highly significant positive correlations between lumbar spine BMD and each of type of sex and sunlight exposure.