الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Enhancing antimicrobial activity in purpose of prevention or at least minimization of microbial resistance to drugs is a challenging objective for the microbiological and pharmaceutical scientists. Alternative strategies are being employed to preserve the efficacy of existing drugs instead of limited introducing of new ones. These include structural modification of existing antibiotics, development of enzyme inhibitors and development of efflux inhibitors which can be coadministered with the antimicrobial agent. The latter may lead to development of additional side effects. Those techniques depend on synthesis of new chemical entity which is a difficult task. Accordingly, a new research line is recently introduced to this field. This line employs new drug delivery systems as a tool to enhance the therapeutic efficacy of antimicrobial agents. Accordingly, the objective of this work was to develop and optimize a colloidal drug delivery system for enhanced antimicrobial activity and reduced resistance to drugs. To achieve this objective niosomes were selected as the colloidal carrier. Norfloxacin and ciprofloxacin were used as model antibacterial agents with ketoconazole and fluconazole being employed as model antifungal agents. P. aeruginosa was used as the test bacteria and Candida albicans was utilized as the test fungi.